True human piebaldism is a rare disorder. Piebaldism involves
distinct patches of skin and hair that contain no pigment. Melanocytes
are completely lacking in these hypopigmented regions. Surrounding
skin and hair show normal pigmentation. Piebaldism often presents
as a white forelock of scalp hair, but patches of depigmented hair
or skin can occur anywhere on the body and there may be more than
one affected area. The difference is that piebaldism is a genetic
abnormality that affects a single, specific gene.
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